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DYSREGULATION OF FOXG1 IN SPATIO-TEMPORAL PATTERNING OF CEREBRAL CORTEX.

ZUFIQKHA IZZATI BINTI ZULKEFLI S55037 BACHELOR OF SCIENCE (BIOLOGICAL SCIENCE)

SUPERVISOR:DR. SHAHIDEE BIN ZAINAL ABIDIN SHAHIDEE.ZAINAL@UMT.EDU.MY CO-SUPERVISOR:DR. SUVIK A/L ASSAW AASUVIK@UMT.EDU.MY

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FOXG1 syndrome is a monogenic neurological orphan disorder caused by a mutation in the FOXG1 gene.  FOXG1 was formerly named Brain Factor 1 due to being the first and most fundamental gene formed during human development. FOXG1 encodes the Forkhead box G1 protein. FOXG1 is a transcription factor gene – it transcodes data to tell our brain how to grow cells and contributes to development of the telencephalon, which is an embryonic structure that gives rise to the cerebrum. Cerebrum is the most important part of the brain – it controls cognition (walking, talking, thinking). The following pathogenic variants have been observed in FOXG1 syndrome patients: deletions, duplications, missense, nonsense, truncation and frame shift variants.

Location Phenotype Phenotype MIM number Inheritance Phenotype mapping key 14q12 Rett syndrome, congenital variant 613454 AD 3

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Problem statement: The hallmarks of FOXG1 syndrome, which results from mutations in a single  FOXG1  allele, include cortical atrophy and corpus callosum agenesis. However, the etiology for these structural deficits and the role of FOXG1 in cortical projection neurons remain unclear.(Cargnin et al., 2018) Significant of study By understanding on the role of  FOXG1  in regulating formation of cerebral cortex it could shed light on the etiology of FOXG1 syndrome Objective To review the molecular basis of cortical hypoplasia in  FOXG1  syndrome

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The research information will be collected from Google Scholar, PubMed,ScienceDirect and ResearchGate by key in keyword such as Foxg1, Foxg1 syndrome and Foxg1 disorder. All the research paper will be downloaded and storing in one specific file in order to keep all the research paper. The usage of Zotero desktop as reference manager will be us to keep track of reference and providing an easy access to the article

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•	 INTRODUCTION •	 BRAIN DEVELOPMENT 1)	ANATOMICAL STRUCTURE OF BRAIN 2)	FORMATION OF SIX-LAYERED NEOCORTEX 3)	MIGRATION MODE OF NEURONE •	 FOXG1 SYNDROME 1.	BRAIN STRUCTURE 2.	CORTICAL DEVELOPMENT AND FOXG1 SYNDROME •	 SPATIO-TEMPORAL DYNAMIC OF FOXG1 IN CREATING CORTICAL CELL DIVERSITY 1)	FOXG1 INSTRUCTS CORTICAL LAMINAR SUBTYPES 2)	FOXG1 BALANCES EXCITATORY AND INHIBITORY IN NEOCORTICAL CIRCUIT 3)	FOXG1 AFFECTS CELLS IN NON-NEURONAL LINEAGE  •	 DISCUSSION 1)	FUTURE DIRECTION/RESEARCH •	 CONCLUSION

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Project activities 2021 2022 July August September October November December January February Preparing written proposal Preparing & submission of proposal video Evaluation and  Q&A session Submission written proposal Data analysis Thesis writing Final presentation Thesis submission

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• References Cargnin, F., Kwon, J.-S., Katzman, S., Chen, B., Lee, J. W., & Lee, S.-K. (2018). FOXG1 orchestrates neocortical organization and cortico-cortical connections.  Neuron ,  100 (5), 1083-1096.e5.  https://doi.org/10.1016/j.neuron.2018.10.016 What is FOXG1 syndrome? —FOXG1 Research Foundation . (n.d.). Retrieved 20 August 2021, from  https://www.foxg1research.org/foxg1syndrome https://www.omim.org/entry/164874

 SUPERVISOR:DR. SHAHIDEE BIN ZAINAL ABIDIN SHAHIDEE.ZAINAL@UMT.EDU.MY CO-SUPERVISOR:DR. SUVIK A/L ASSAW AASUVIK@UMT.EDU.MY

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 • References Cargnin, F., Kwon, J.-S., Katzman, S., Chen, B., Lee, J. W., & Lee, S.-K. (2018). FOXG1 orchestrates neocortical organization and cortico-cortical connections.  Neuron ,  100 (5), 1083-1096.e5.  https://doi.org/10.1016/j.neuron.2018.10.016 What is FOXG1 syndrome? —FOXG1 Research Foundation . (n.d.). Retrieved 20 August 2021, from  https://www.foxg1research.org/foxg1syndrome https://www.omim.org/entry/164874

DYSREGULATION OF FOXG1 IN SPATIO-TEMPORAL PATTERNING OF CEREBRAL CORTEX.

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