Name: WARFARIN PHARMACOLOGY
Uploaded: 2022-08-23
Duration: 1 min 55 s
Description: WARFARIN PHARMACOLOGY. Two Ways to Reduce Blood Thinner Risks That Lead to GI Bleeding.

WARFARIN PHARMACOLOGY. Two Ways to Reduce Blood Thinner Risks That Lead to GI Bleeding. 

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Two Ways to Reduce Blood Thinner Risks That Lead to GI Bleeding

Pharmacokinetics. 100% oral bioavailability. 99% warfarin bound to plasma albumin. 

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[Audio] Vitamin k epooxide is reduced to vitamin k hydroquinone, which act as cofactor for gamma carboxylase to activate 4 vitamin K dependent factors. Warfarin inhibits the reduction of vitamin k epoxide, thus activate coagulation factors synthesis is inhibited partially.. 

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Why there is delay in warfarin action?. There is an 8-12 hours delay in warfarin action.. 

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There is an 8-12 hours delay in warfarin action.

Its anticoagulant effect results from partially inhibited synthesis &  unaltered degradation of preformed four vitamin-K dependent clotting factors.

How warfarin cause transient hypercoagulable state?. 

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How warfarin cause transient   hypercoagulable  state?

Hypercoagulable  state is  a condition that causes your  blood to clot more easily  than normal protein  C  has a  short  half-life  similar  to factor  VIIa , so degraded & depleted rapidly.  Thus  the immediate effect of warfarin is to deplete the  procoagulant  factor VII and anticoagulant protein C, which  can paradoxically  create a transient  hypercoagulable  state due to residual  activity of the longer half-life  procoagulants   in the face of  protein C depletion

Warfarin drug interactions. Increase prothrombin time. 

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WARFARIN PHARMACOLOGY

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Vitamin k epooxide is reduced to vitamin k hydroquinone, which act as cofactor for gamma carboxylase to activate 4 vitamin K dependent factors.

Warfarin inhibits the reduction of vitamin k epoxide, thus activate coagulation factors synthesis is inhibited partially.

WARFARIN PHARMACOLOGY

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