Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression

Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression.

Summary. Major depressive disorders (MDD) Rho- gtpase and Rac1 Epigenetic regulation of Rac1 in chronically stressed mice and depressed individuals Therapeutic approaches for treating depression.

Background information. Rho- gtp proteins regulate synaptic structure and depression-related behaviors Rac1 Nucleus accumbens of mice ( NAc ).

Treating depression.

Experimental set up. Diagram Description automatically generated.

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Epigenetic mechanism. Chart, bar chart Description automatically generated.

Epigenetic rescue of the Rac1 downregulation of susceptible mice.

Regulation of RAC1 in subjects with MDD. Chart, scatter chart Description automatically generated.

Epigenetic regulation of RAC1 mRNA expression in subjects with MDD..

Rac1 controls stress-induced formation of excitatory spines.

Identification of limitations as well as further studies needed.