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O- GlcNAcylation   promotes   osteoclastogenesis   and   dictates   the   resorption   mode   by   osteoclasts

Ph.D : Thaise  Mayumi  Taira Supervisor: Prof. Dr. Sandra  Yasuyo   Fukada

UNIVERSITY OF SÃO PAULO SCHOOL OF PHARMACEUTICAL SCIENCES  OF RIBEIRÃO PRETO

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Trap MMP-9 CtsK Boyle et al., 2003 Kalervo-Vaananen  et al., 2008 Qin et al., 2012 Teti, 2013

Glucose  HEXOSAMINE BIOSYNTHETIC PATHWAY (HBP)

What   is   the  role  of  O- GlcNAcylation   on   osteoclastogenesis ?

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Evaluate the role of O-GlcNAcylation on osteoclast’s differentiation  and function.

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O- GlcNAcylation   participates   on   osteoclasts   differentiation   and   fusion

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O- GlcNAcylation   affects   the   type   of   osteoclasts   resorption

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✓ O- GlcNAcylation   stimulates   osteoclastogenesis  in vitro; ✓ O- GlcNAcylation   coordinates   osteoclasts’s   agressiveness  for  bone   resorption .

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Profa. Sandra  Y .  Fukada   –   Supervisor  (FCFRP-USP) Prof. Kent  Søe - Colaborador (SDU  –   Denmark ) Prof.  Erivan   Shineider  Ramos Junior  –   Colaborator  (Augusta  University )  Cecília Costa do Carmo e Silva  –   Student  (FCFRP-USP) Mayara Santos Gomes  –   Laboratory   Technitian  (FCFRP-USP) Jacob  Bastholm   Olesen   –   Laboratory   Technitian  (SDU)

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