Name: Tablets
Uploaded: 2022-06-11
Duration: 1 min 7 s
Description: Tablets. by Tapamoy Chakraborty pHarmaVa (google.com).

Tablets. by Tapamoy Chakraborty pHarmaVa (google.com). 

Scene 1

by Tapamoy Chakraborty  pHarmaVa   (google.com)

A  tablet  (also  known as a  pill )  is a  pharmaceutical  oral  dosage  form ( oral  solid  dosage , or OSD) or solid  unit   dosage form.  Tablets  may be  defined  as  the  solid unit  dosage form  of medicament  or  medicaments with   suitable  excipients . It comprises  a mixture  of active  substances and  excipients,  usually in  powder  form,  pressed  or  compacted from  a  powder  into a  solid   dose. Tablets  are  prepared either  by molding or by  compression . The  excipients  can  include  diluents ,  binders  or   granulating  agents,  glidants  (flow aids) and  lubricants  to  ensure efficient  tabletting;  disintegrants  to  promote   tablet   break-up   in   the   digestive   tract;   sweeteners   or   flavours   to   enhance   taste;   and   pigments   to   make   the   tablets   visually  attractive  or aid  in visual identification of  an  unknown  tablet. A  polymer coating  is  often applied to  make  the tablet   smoother  and  easier  to swallow, to  control  the release  rate  of  the active  ingredient,  to  make it more  resistant to  the environment (extending its shelf  life), or  to  enhance  the tablet's appearance. Medicinal tablets  were  originally   made  in the  shape  of  a  disk  of  whatever color their  components  determined,  but are now made in  many  shapes  and colors  to help distinguish different  medicines.  Tablets  are  often stamped with symbols, letters,  and  numbers,   which  enable them to  be identified.  Sizes  of  tablets to  be  swallowed range from  a few  millimetres to  about a   centimetre. The  compressed tablet  is  the  most  popular  dosage form  in  use  today.  About  two-thirds of all  prescriptions  are   dispensed as solid  dosage  forms, and  half  of these are compressed  tablets.  A tablet can be formulated  to  deliver  an  accurate  dosage  to  a specific  site;  it is usually taken  orally,  but can  be  administered  sublingually ,  buccally ,  rectally  or  intravaginally .  The  tablet  is just one  of the  many forms  that  an  oral   drug can  take such  as  syrups ,  elixirs ,  suspensions ,  and   emulsions . Model  compounds The  compounds and  size  fractions were used  in the studies:  sodium chloride  (125-180  µm, 355-500 µm),   sodium  bicarbonate (raw material,  45-63  µm, 125-180 µm), calcium carbonate (raw material),  mannitol   (250-  425  µm) and  dibasic  calcium phosphate dihydrate (DCP;  90-180  µm).  The  different  size  fractions were  obtained  by dry  sieving (Retsch,  Germany).  The term  compound is used throughout  this  thesis  for  materials   that  are  not  used as   binders. Binder   materials The binder  materials  were  used  in the  studies: polyethylene glycol  (PEG) 3000,  PEG  6000,  PEG  10000,  PEG   20000,  microcrystalline  cellulose (MCC),  silicified microcrystalline  cellulose  (SMCC), pregelatinised starch   (PGS),  polyvinylpyrrolidone  (PVP),  α-lactose monohydrate (crystalline lactose),  partially  crystalline lactose  and amorphous   lactose. Superdisintegrant Crosslinked carboxymethyl  cellulose sodium  (Ac-Di-Sol) was used as superdisintegrant. All  powders  were  stored at  40%  relative  humidity (RH)  (saturated  chrome trioxide in  water) (Nyqvist, 1983), except  partially   crystalline and  amorphous  lactose, which  were  stored at  0%  RH  (phosphorus  pentoxide), and all were  stored   at  room  temperature  for at  least  48 hours  before characterisation,  mixing  and   compaction.

Tablets

Scene 0

 by Tapamoy Chakraborty  pHarmaVa   (google.com)

slide1-hotlink5

 A  tablet  (also  known as a  pill )  is a  pharmaceutical  oral  dosage  form ( oral  solid  dosage , or OSD) or solid  unit   dosage form.  Tablets  may be  defined  as  the  solid unit  dosage form  of medicament  or  medicaments with   suitable  excipients . It comprises  a mixture  of active  substances and  excipients,  usually in  powder  form,  pressed  or  compacted from  a  powder  into a  solid   dose. Tablets  are  prepared either  by molding or by  compression . The  excipients  can  include  diluents ,  binders  or   granulating  agents,  glidants  (flow aids) and  lubricants  to  ensure efficient  tabletting;  disintegrants  to  promote   tablet   break-up   in   the   digestive   tract;   sweeteners   or   flavours   to   enhance   taste;   and   pigments   to   make   the   tablets   visually  attractive  or aid  in visual identification of  an  unknown  tablet. A  polymer coating  is  often applied to  make  the tablet   smoother  and  easier  to swallow, to  control  the release  rate  of  the active  ingredient,  to  make it more  resistant to  the environment (extending its shelf  life), or  to  enhance  the tablet's appearance. Medicinal tablets  were  originally   made  in the  shape  of  a  disk  of  whatever color their  components  determined,  but are now made in  many  shapes  and colors  to help distinguish different  medicines.  Tablets  are  often stamped with symbols, letters,  and  numbers,   which  enable them to  be identified.  Sizes  of  tablets to  be  swallowed range from  a few  millimetres to  about a   centimetre. The  compressed tablet  is  the  most  popular  dosage form  in  use  today.  About  two-thirds of all  prescriptions  are   dispensed as solid  dosage  forms, and  half  of these are compressed  tablets.  A tablet can be formulated  to  deliver  an  accurate  dosage  to  a specific  site;  it is usually taken  orally,  but can  be  administered  sublingually ,  buccally ,  rectally  or  intravaginally .  The  tablet  is just one  of the  many forms  that  an  oral   drug can  take such  as  syrups ,  elixirs ,  suspensions ,  and   emulsions . Model  compounds The  compounds and  size  fractions were used  in the studies:  sodium chloride  (125-180  µm, 355-500 µm),   sodium  bicarbonate (raw material,  45-63  µm, 125-180 µm), calcium carbonate (raw material),  mannitol   (250-  425  µm) and  dibasic  calcium phosphate dihydrate (DCP;  90-180  µm).  The  different  size  fractions were  obtained  by dry  sieving (Retsch,  Germany).  The term  compound is used throughout  this  thesis  for  materials   that  are  not  used as   binders. Binder   materials The binder  materials  were  used  in the  studies: polyethylene glycol  (PEG) 3000,  PEG  6000,  PEG  10000,  PEG   20000,  microcrystalline  cellulose (MCC),  silicified microcrystalline  cellulose  (SMCC), pregelatinised starch   (PGS),  polyvinylpyrrolidone  (PVP),  α-lactose monohydrate (crystalline lactose),  partially  crystalline lactose  and amorphous   lactose. Superdisintegrant Crosslinked carboxymethyl  cellulose sodium  (Ac-Di-Sol) was used as superdisintegrant. All  powders  were  stored at  40%  relative  humidity (RH)  (saturated  chrome trioxide in  water) (Nyqvist, 1983), except  partially   crystalline and  amorphous  lactose, which  were  stored at  0%  RH  (phosphorus  pentoxide), and all were  stored   at  room  temperature  for at  least  48 hours  before characterisation,  mixing  and   compaction.

Tablets

Scene 1 (0s)