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For enquiries please email both:  Simisola  @  1715904@students.wits.ac.za Kundai  @   1589308@students.wits.ac.za

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Two-  phase system with uniform  dispersion. Dispersed phase Continuous  phase .

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Drug molecules with  low solubility. To mask the taste of an unpleasant tasting drug (in it’s   soluble form). Faster dissolution rate compared to solid  dosage forms. Stability of drugs – mixed prior to use and given a short expiry date (e.g. mix antibiotics in pharmacy for patients). Prolonged effect if given in the insoluble form e.g. intramuscular injections.  Prolonged effect topically as solid remains on the skin for longer.

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Easy to re-disperse by shaking when sediment forms.  Pourable . Insoluble particles stay in suspension long enough → accurate dose can be measured. Particles size:  Small, uniform and free  from grittiness .

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Suspending agents To reduce sedimentation. 	Over time particles settle on the bottom and may be difficult to  re-disperse . ( If ↑ η  (viscosity)  continuous  phase or ↓ particle size ) Flocculating agent To prevent  caking of suspended  particles.   	Deflocculated suspension is difficult to  re-disperse .  	Flocculated reduce  pourability .  Wetting  agent  To  improve the flow of the liquid vehicle across the particle surface, which in turn improves the homogeneity of distribution of the drug particles throughout the formulation.  	Air trapped on particles → float on suspension are not dispersed

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Formulation  1:  Paediatric  Chalk Mixture  BP Formulation 2: Kaolin and Morphine Mixture BP  Formulation 3: Calamine  Lotion.

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Learn how to write a label. Learn abbreviations (prn,bd,tds,mitte ). Expiry  is 2  weeks from date of manufacture unless stated otherwise Method is ALWAYS in past tense . Get the required amount of chemical, don’t be wasteful. Relationship b/w SG and density: SG of water = 1.  If  SG of substance is more than 1, it is more dense than water and the opposite is true.


Lab 2
Suspensions


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 For enquiries please email both:  Simisola  @  1715904@students.wits.ac.za Kundai  @   1589308@students.wits.ac.za  

Lab 2 Suspensions

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