PSORIASIS

[Audio] Good morning everyone. Today, we will be discussing psoriasis – a condition that affects many people around the world. We'll be looking at its causes, associated conditions, and types of arthritis, along with its histopathological findings and pathogenesis. To start, let's introduce the topic of psoriasis..

[Audio] Psoriasis is a skin condition that affects a large number of people globally. Studies have indicated that as many as 7.5% of people may suffer from psoriasis, with an estimated total of 125 million individuals currently living with the condition. This skin disorder does not differentiate by race, age or gender, making it one of the most wide-spread..

[Audio] Psoriasis is an incurable skin condition, affecting up to 2 percent of the population worldwide. It typically causes itchy and scaly patches of skin on various parts of the body, which can be red, white or silvery and can range from mild to severe. Psoriasis is a chronic condition and is managed long-term with various treatments such as topical ointments and light therapy. People suffering from psoriasis may need to make lifestyle adjustments and receive medical care..

[Audio] The cause of psoriasis is uncertain, but it is believed to be linked to an issue with the immune system. Many different things — such as genetics, environment, lifestyle, stress, medications and infections — can cause psoriasis..

A: Psoriasis is a chronic condition caused by a combination of genetic predisposition and triggering factors such as infections (e.g., streptococcal pharyngitis, HIV) or certain medications (interferon, β-blockers, lithium, oral corticosteroid taper)..

[Audio] In the 19th century, Heinrich Koebner first described the phenomenon seen in psoriasis that skin injury or trauma can trigger the development of psoriasis plaques in an otherwise healthy area of skin, known as the Koebner phenomenon. This phenomenon is most commonly seen in areas exposed to constant or repetitive friction, like the hands, feet, trunk, or scalp..

[Audio] The Koebner phenomenon is characterized by the appearance of psoriatic lesions in areas of skin trauma, such as scrapes, burns, or cuts. Studies indicate that up to a third of psoriasis patients will experience this reaction to an injury. The cause of the Koebner phenomenon is unknown, but it is speculated to be related to the abnormal production of skin cells in psoriasis, and thus an altered response to trauma as compared to normal skin cells..

[Audio] Psoriasis typically affects the skin on the elbows, knees, scalp, and lower back, though it can appear on any part of the body. It is an autoimmune disorder which results in skin cells over-producing as well as inflammation and discomfort. It affects about 2% of the population and can range in severity. Treatment involves lifestyle changes such as managing stress as well as topical treatments and systemic treatments..

[Audio] Psoriasis is a skin condition that affects many people around the world. It typically appears as red, crusty patches of skin covered with silvery scales. While it can affect almost any part of the body, it commonly appears on the scalp, elbows, knees, nails, hands, feet, and the skin between the buttocks. Treatments for psoriasis aim to reduce inflammation and slow down the skin cell growth that leads to patch formation..

[Audio] Psoriatic skin lesions typically appear as red, scaly patches on the skin. They commonly form on elbows, knees, scalp, and lower back, but can appear anywhere including the face, nails, and joints. They can range in size from small to covering large areas of the body, and may itch or burn..

[Audio] Psoriasis is a common condition characterized by red, scaly patches on the skin caused by the overproduction of cells. These patches can be well-demarcated and covered in silvery scales, while in other cases pustules and glistening plaques may also appear. It is a chronic condition that requires prompt medical attention..

[Audio] Psoriasis is a long-term inflammatory skin disorder characterised by raised, red plaques with a silvery white accumulation of dead skin cells on the surface called scale. Histological aspects related to psoriasis are atypical multiplication of epidermal cells, diminishing of the epidermis, and epidermal neutrophils. In addition, psoriasis has the capacity to create microabscesses, thickening of the dermis, and increased number of capillaries in the dermis..

[Audio] Psoriasis is a skin condition characterized by red, scaly patches on the skin, which can become itchy and painful. Histopathology is involved in its diagnosis, and biopsy results reveal that the skin layers are thickened, with excessive keratinization, neutrophils, a decreased granular layer and dilated blood vessels. In some cases, additional treatment may be necessary to manage the condition..

[Audio] Psoriasis is a frequent skin condition that predominantly affects the scalp, elbows, and knees. There is no sure way to heal psoriasis, but it can be managed with treatments and lifestyle alterations. Psoriatic arthritis is one of the major associated conditions of psoriasis which affects the joints nearby the affected skin area. Manifestations of psoriatic arthritis incorporate joint pain, stiffness, soreness, swelling and even exhaustion. Treatment for psoriatic arthritis centers around controlling the indications and avoiding joint and tissue harm..

[Audio] Psoriatic arthritis is a condition often linked to psoriasis, typically characterized by swollen joints in the hands and feet. Additionally, metabolic syndrome is known to occur frequently in individuals with psoriasis..

[Audio] Psoriasis is a chronic autoimmune skin disorder characterized by redness, inflammation, and the formation of raised scales on the skin. The cause is unknown, but appears to be associated with an overactive immune system leading to increased production of an inflammatory protein called cytokines. This increased cytokine production leads to an overproduction of skin cells, resulting in scaly patches of skin..

[Audio] Psoriasis is a long-term inflammatory skin disorder that affects millions of individuals in the US alone and even more worldwide. Recent research has revealed that the condition is caused by both genetic and cytokine factors, in particular TNF-α and IL-23, which in turn activate Th17 cells. This has enhanced our comprehension of what causes the disorder and introduced potential new treatments and therapies..

[Audio] Psoriatic arthritis is characterized by five distinct forms: symmetric polyarthritis, asymmetric oligoarticular arthritis, distal interphalangeal predominant arthritis, spondyloarthritis, and arthritis mutilans. Of these, the most common is symmetric polyarthritis, which manifests in a symmetrical way, impacting the same number of joints on both sides of the body..

[Audio] Psoriatic arthritis can have an effect on joints in many forms. It can affect one or several joints and show up as inflammation of the distal interphalangeal joints, similar to rheumatoid arthritis, or as arthritis mutilans, spondylitis, and sacroiliitis. All of these can hinder a person's ability to do day-to-day activities..

Q: Can you provide examples of psoriatic arthritis types?.

[Audio] Psoriatic arthritis is an inflammatory condition that can cause inflammation in joints and other body areas, and can affect up to 30% of people with psoriasis. There are five possible types of psoriatic arthritis that can be present: mono- and asymmetric oligoarthritis, arthritis of the distal interphalangeal joints, rheumatoid arthritis-like presentation, arthritis mutilans, and spondylitis and sacroiliitis. The complexity of these presentations makes psoriatic arthritis difficult to treat, so it is vital for healthcare professionals to have an extensive understanding of the condition..