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Now – Spread in over 200 countries (WHO)

January 30, 2020 - PHEIC
February 11, 2020 - Named SARS-CoV-2

COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU)
Total Confirmed
Confirmed Cases by
Co untry/Region/So Vere ig nty
us
Spain
Italy
France
Germany
United Kingdom
Turkey
Iran
China
Russia
AdminO
4/24/2020 2:31
Au s TRALIA
Testing Rate
ANTARCTICA
Cumulative Confirmed Active I Rate Case-Fata lity Ratio
Lancet Inf Dis Article: Here. Mobile Version: Here.
185
Hospitalization Rate
Lead by JHU CSSF. Automation Support: Fsri Living Atlas team and JHU APL Contact FAO.
187,330
25,549 deaths
22,157 deaths
Spain
21 ,856 deaths
France
18,738 deaths
United Kingdom
15,014 deaths
New York City
New York US
Deaths Recovered
Logarithm i c
4,493, 106
695,920 tested
New York US
482,097 tested
California US
296,708 tested
Florida US
225,018 tested
Texas US
148 tested
New Jersey US
US
Daily Cases

Scene 3

Order
Family
Subfamily
Genus Alpha
Coronaviridae
N/DOVIRALES
Torovirinae
Corona virinae
Beta Gamma
I coronavirus coronavirus coronavirus
I Torovirus Bafinivirus
Delta
coronavirus I
Lineage

COV
ßCoVA
ßCoVD
go.B&C0V HKU9
SARSr-Rh.batCOV„aoV
SARSr-CiCoV
ßCoVB
ßCovc
0.05
WECOVHKU16
ThCov HKUI 2
Bucov HKU' 1
cov
a COV
Mi-BatcoV 1B
HCOV-229E
-Coy

The SARS-CoV-2 virus that causes COVID-19 belongs to the 
Coronaviridae family.

Scene 4

Spike Glycoprotein (S)
Get the virus into the cell

Hemagglutinin-esterase (HE)
May facilitate the virus to initially adsorb 
the cell membrane

RNA and N Protein
N protein is related to the formation of 
nucleocapsid in RNA genome

E-Protein
The smallest and most mysterious

M-Protein
Virus germination and envelope formation

Scene 5

Attachrnont and entry
Spike protein
ACQ V
Translation ot ORF1a
and ORF1b
RNA gnymerase
Transcription
Replication
Viral release
Rus
Translation
(positive)

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Screen the existing broad-spectrum 
antiviral drugs.

Use existing molecular libraries and 
databases to screen for molecules that may 
have a therapeutic effect on SARS-CoV-2.

Develop specific drugs based on the 
genomic information and pathological 
characteristics of SARS-CoV-2.

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•
Enhance immune response - such as the 
release of interferon.

•
Block the signal pathways 
required for virus replication.

•
Target viral and cell surface receptor 
proteins (ACE2).

2019. ncoV
ACE-2 r«eptor
Human
Cell
Target
ACE2-Fc

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•
Prevent viral RNA synthesis - target
to the genetic material of the virus.

•
Inhibit virus replication - target to
key enzymes of the virus.

•
Block the virus’s binding to human 
cell receptors or inhibiting the 
virus’self-assembly process - target
to the structural proteins of the virus.

Scene 9

Monoclonal antibody/convalescent plasma for ACE2: 
Prevent the virus into the host cell.
1

science.sciencemag.org/content/367/6485/1412

Camostat mesylate: Prevent SARS-CoV-2 into the cell 
by acting on TMPRSS2.
2

Lopinavir-Ritonavir: Inhibition of protease activity of 
SARS-CoV-2.
3

RNA Synthesis Inhibitors: Inhibits SARS-CoV-2 RNA 
synthesis and replication.
5

Neuraminidase Inhibitors (NAIs)-Interfere with the 
release of progeny influenza virus from infected 
host cells.
66

Ia Fusion
SARS-CoV-2)
Cell
convalescmt plasma
Camostat
mesylate
TMPRS2
ACE2
1b Endocytosis
Chloroquine,
hydroxychloroquine
2 Translation
Viral Rib(ßornes
RNA
3 Proteolysis
Lopinavir-ritonavir
Replication-
transcription complex
RNA•dependent
RNA polymerase
Remdesivir
RNA Synthesis
C
4 Translation and RNA replication.—— inhibitors
5 Packaging
6 Virion
00
NAIs
Golgi
Endoplasmic
reticulum

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•
Antibody & Immunoassay Development Services

•
Molecular Diagnostic Assay Development Services

Scene 11

Antibody
Recombinant Proteins
Plasmids
PCR Primers & Probes
Detection Kits

Antibody
Recombinant Proteins
Plasmids
Protein Expression Products

Scene 12

Address: 45-1 Ramsey Road, Shirley, NY 11967, USA

CreY)/Za tive Diolabs@
Contact Us
Web: www.creative-biolabs.com
Email: info@creative-biolabs.com
Address: 45-1 Ramsey Road, Shirley,

PowerPoint 演示文稿

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RNA Synthesis Inhibitors: Inhibits SARS-CoV

SARS-CoV-2 Treatment Strategies   NAIs   RNA Synthesis

SARS-CoV-2 Preclinical Research   Drug Discovery Services   In Vitro Diagnostic

Immunoassay Development Services   Creative Biolabs

Molecular Diagnostic Assay Development Services

Plasmids PCR Primers & Probes Detection Kits   SARS-CoV

Antibody Recombinant Proteins Plasmids Protein Expression Products

MERS-CoV   Antibody Recombinant Proteins Plasmids Protein Expression Products

RNA Extraction Kit   Antibody Recombinant Proteins Plasmids Protein Expression Products

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