Proton Online Talk for doctors_HNC_20240425

[Virtual Presenter] Today we will discuss how Wing-Keen Yap a Clinical Lecturer and Consultant Radiation Oncologist at Linkou Chang Gung Memorial Hospital is innovating in cancer treatments with Proton Beam Therapy. We will explore the implications of this life-saving technology its potential to treat head and neck cancers and Dr Yap's dedication to advancing this field of medicine..

[Audio] Proton Beam Therapy is a form of radiotherapy which uses protons to treat cancer. It is highly effective in targeting cancerous tissue thus minimizing damage to the surrounding healthy tissue. This makes it an ideal form of treatment for head and neck cancers as it can minimize side effects. This article will discuss the various applications of proton beam therapy in the treatment of these cancers..

[Audio] EBRT short for External Beam Radiotherapy is the most prevalent type of radiotherapy. It involves using radiation beams administered from outside the body to target the cancer cells and destroy them while reducing the damage inflicted on healthy tissue. Leading the way to optimizing the effectiveness of E-B-R-T in treating cancer is Wing-Keen Yap MD..

[Audio] Dr Wing-Keen Yap is making advances in cancer treatment through Proton Beam Therapy for Head and Neck Cancers. Particle beam photon beam and External Beam Radiation Therapy also known as E-B-R-T are among the types of ionizing radiation utilized in this form of treatment. This type of radiation is used to focus on and devastate malignant cells while limiting any potential damage to healthy cells that are in close proximity..

[Audio] Proton therapy is a highly advanced radiation therapy that is used in cancer treatment. It employs high-energy protons to deliver pinpoint radiation which results in minimal harm to nearby healthy tissue. This allows physicians to increase radiation doses to tumors compared to traditional radiation therapy which enhances the therapeutic effects. Furthermore bespoke doses can be generated which enable a safer and more exact treatment. In comparison to conventional radiation therapy proton therapy also requires a shorter period of treatment resulting in a better quality of life for patients. This is especially beneficial when treating head and neck cancers as these areas usually contain sensitive sites. Wing-Keen Yap MD is working hard to make this form of therapy more accessible for patients..

Proton Therapy is an Advanced and Highly Precise form of EBRT.

[Audio] Wing-Keen Yap MD is a Clinical Lecturer and Consultant Radiation Oncologist at Linkou Chang Gung Memorial Hospital where he works to advance cancer treatment with Proton Beam Therapy for Head and Neck Cancers. Potential benefits from this newer form of therapy versus X-ray or conventional radiation therapy include the ability to increase the dose to the tumor which boosts the chance for cure. It also reduces the dose to nearby sensitive organs and normal tissue thereby reducing potential side effects. Proton therapy also reduces the integral dose which can reduce the risk for radiation-induced malignancy. This risk is particularly important to consider in younger patients where the median latency time for radiation-induced malignancy can be as long as 7-10 years..

[Audio] Wing-Keen Yap MD is a Clinical Lecturer and Consultant Radiation Oncologist at Linkou Chang Gung Memorial Hospital where the Linkou Chang Gung Proton and Radiation Therapy Center has been using Sumitomo’s Proton Therapy system since 2015. This includes a Cyclotron 230MeV Beam Transport System and a 360 degrees Rotational Gantry Treatment Room. The Center has three rooms for pencil beam scanning and one room for passive scattering beam for moving targets which helps in treating Head and Neck Cancers with Proton Beam Therapy..

[Audio] Wing-Keen Yap MD is a Clinical Lecturer and Consultant Radiation Oncologist at Linkou Chang Gung Memorial Hospital. He is working to advance cancer treatment with Proton Beam Therapy for Head and Neck Cancers. The three types of radiation therapy used to treat head and neck cancers are X-Ray (I-M-R-T-) Proton Beam Therapy (P-S-P-T-) and Proton Beam plus Photon Therapy (I-M-P-T-). X-ray beams are the oldest form and most widely used radiation therapy. This process involves using x-rays to treat the tumor from outside the body. Proton Beam Therapy is a newer form of radiation therapy. It involves using protons instead of x-rays to treat the tumor from outside the body. Proton Beam plus Photon Therapy is an advanced form of radiation therapy that combines proton beams with photon radiation. This combination therapy offers the most precise form of radiation therapy available. In conclusion Dr Yap is using Proton Beam Therapy to advance cancer treatment for Head and Neck Cancers. His research and dedication to this new form of therapy is helping to improve outcomes for patients around the world." Dr Yap's work to advance cancer treatment with Proton Beam Therapy for Head and Neck Cancers is remarkable. He is using three different forms of radiation therapy to achieve the most precise treatment available with the best outcomes for patients. X-Ray (I-M-R-T-) is the oldest form and most widely used radiation therapy while Proton Beam Therapy (P-S-P-T-) and Proton Beam plus Photon Therapy (I-M-P-T-) are newer forms of radiation therapy. These two forms of radiation therapy involve using protons and a combination of protons and photons to treat the tumor from outside the body respectively. By utilizing these therapies Dr Yap is helping to improve the lives of those suffering from cancer..

[Audio] Wing-Keen Yap MD is leading a dedicated team of clinicians and researchers to advance cancer treatment with Proton Beam Therapy at Linkou Chang Gung Memorial Hospital. This specialized technique is used to target malignant tumors in the head and neck region. But this therapy is also used to treat others types of cancer ranging from liver brain and breast cancers to pancreas cholangio and rectal cancers as visualized in the data presented in this slide. The pioneering contributions of Dr Yap and his team are improving the quality of life for many patients while paving the way for even more advanced advances in the future..

[Audio] Dr Wing-Keen Yap is a Clinical Lecturer and Consultant Radiation Oncologist at Linkou Chang Gung Memorial Hospital striving to advance cancer treatment with Proton Beam Therapy for Head and Neck Cancers. This sophisticated form of radiation therapy uses highly charged particles to precisely target cancer cells while minimizing damage to surrounding tissues. Studies conducted by Dr Yap and his team have shown that Proton Beam Therapy is a safe and effective form of treatment for head and neck cancers as well as offering promise for other cancers. Through their pioneering efforts Dr Yap and his team are making great strides in advancing cancer treatment providing hope for cancer patients everywhere..

[Audio] Dr Wing-Keen Yap is a committed doctor and researcher who works with the newest technology to advance cancer treatment. Proton Beam Therapy is a promising technology that could be used for treating Head and Neck Cancers. Its physical advantages over photon therapy make it useful for treating complex anatomies with nearby sensitive organs. It can offer greater reduction of short and long-term side effects compared to other therapies and for certain tumors it can bring about better control and longer survival..

[Audio] Wing-Keen Yap a radiation oncologist is researching ways to enhance cancer treatment with proton beam therapy for head and neck cancers which has a dosimetric benefit of diminishing dose to healthy tissue with unilateral irradiation or IMPT. This gain has been shown in papers such as Leeman's 2017 Lancet Oncology paper. Yap's work is enlarging our insight of this kind of cancer treatment and its capability to reduce healthy tissue harm..

[Audio] Wing-Keen Yap MD of Linkou Chang Gung Memorial Hospital is aiming to improve cancer treatment by utilizing proton beam therapy particularly for head and neck cancers. According to the Blanchard study from 2018 proton beam therapy has dosimetric benefits in comparison to other forms of treatment these benefits include improved target coverage as well as reduction of radiation doses to nearby organs. With these capabilities this kind of therapy can treat cancer while minimizing the risk of adverse effects..

[Audio] Wing-Keen Yap is a Clinical Lecturer and Consultant Radiation Oncologist at Linkou Chang Gung Memorial Hospital. He specializes in utilizing Proton Beam Therapy for Head and Neck Cancers. As an example Yap and his team recently treated a 67-year-old man with right tongue base cancer stage T2N2b H-P-V plus Grade 3. The team employed an Intensity Modulated Radiotherapy approach to treat the patient. This technique uses advanced computer technologies to shape the radiation beam to the contours of the tumor creating indistinct borders of mucositis and granting the patient the best possible level of treatment..

[Audio] Dr Wing-Keen Yap is a renowned radiation oncologist who is known for pioneering proton beam therapy in the treatment of head and neck cancers. He has actively worked on minimizing the side effects of the radiation therapy such as P-E-G or NG tube insertions mucositis odynophagia nausea/vomiting weight loss xerostomia and dysphagia. His research also focuses on identifying the dose distributions for the therapy as well as maintain the taste..

[Audio] Wing-Keen Yap MD is a Clinical Lecturer and Consultant Radiation Oncologist at Linkou Chang Gung Memorial Hospital in Taiwan. He is leading a research team that is exploring the use of Intensity Modulated Proton Beam Therapy and Volumetric ModulatedArc Therapy for the treatment of nasopharyngeal cancer. The team recently published a paper in Cancers titled "Intensity Modulated Proton Beam Therapy versus Volumetric Modulated Arc Therapy for Patients with Nasopharyngeal Cancer: A Propensity Score-Matched Study". This study is aimed at advancing the treatment of head and neck cancers with Proton Beam Therapy. The results of the study will be beneficial in helping to shape clinical decisions and improve the outcomes for patients with these cancer types..

[Audio] Wing-Keen Yap a Clinical Lecturer and Consultant Radiation Oncologist at Linkou Chang Gung Memorial Hospital is using Proton Beam Therapy for Head and Neck Cancers to progress cancer treatment. To assess the efficacy of this therapy a retrospective propensity score matching analysis was conducted with 80 pairs of patients between 2016 and 2018 for the I-M-P-T group and 2014 and 2018 for the V-M-A-T group. The median follow-up time for the I-M-P-T group was 24.1 months..

[Audio] Dr Wing-Keen Yap a Clinical Lecturer and Consultant Radiation Oncologist at Linkou Chang Gung Memorial Hospital is researching the possibility of using Proton Beam Therapy to improve the outcomes of cancer treatment for Head and Neck Cancers. This slide looks at the toxicity analysis for two methods intensity-modulated proton therapy and volumetric modulated arc therapy by examining variables such as nasogastric tube placement percentage body weight loss weight loss over 7% grade 3 dermatitis with wound care grade 3 mucositis grade 2 to 4 xerostomia emergency room visits and unscheduled hospitalization. The results of the comparison revealed that intensity-modulated proton therapy had a statistically significant lower toxicity rate than volumetric modulated arc therapy leading to hope that proton beam therapy will be useful in improved cancer treatment for head and neck cancers..

[Audio] A team of esteemed doctors from Chang Gung Memorial Hospital's Proton and Radiation Therapy Center led by Dr Wing-Keen Yap conducted a study investigating the toxicity profiles and survival outcomes of patients with nonmetastatic nasopharyngeal carcinoma treated with Intensity-Modulated Proton Therapy (I-M-P-T-) versus Intensity-Modulated Radiation Therapy (I-M-R-T-). The research team gathered data on long-term outcomes of these treatments providing insight into the value of I-M-P-T for head and neck cancers..

[Audio] Wing-Keen Yap MD is a Clinical Lecturer and Consultant Radiation Oncologist at Linkou Chang Gung Memorial Hospital. He is actively researching ways to improve the treatment of cancer using Proton Beam Therapy for Head and Neck Cancers. With this goal in mind Yap and his team conducted a study comparing Intensity Modulated Proton Therapy (I-M-P-T-) to Intensity Modulated Radiation Therapy (I-M-R-T-) in the treatment of these cancers. The results of the study indicated that I-M-P-T was associated with a significantly decreased risk of severe acute adverse events compared to IMRT. The findings of this study offer potential to use I-M-P-T with head and neck cancer patients in the future..

[Audio] Wing-Keen Yap MD a clinical Lecturer and Consultant Radiation Oncologist at Linkou Chang Gung Memorial Hospital is leading a team of researchers whose work is testing the efficacy of proton beam therapy in the treatment of head and neck cancers. Dr Yap's team is comparing the dose toxicity of proton versus photon radiation in order to better understand the impact of proton beam therapy in cancer treatment. Their work has been published in the Lancet Oncology journal and is based on data from multiple studies on direct comparisons of proton versus photon toxicity." Dr Wing-Keen Yap and his team are investigating the use of proton beam therapy in the treatment of head and neck cancers. By comparing the dose toxicity of proton versus photon radiation they are working to understand the impact of proton beam therapy. Their groundbreaking research has been published in the Lancet Oncology journal and is based on data from numerous studies on direct comparisons of proton versus photon toxicity..

[Audio] Wing-Keen Yap MD is a radiation oncologist at Chang Gung Memorial Hospital and he is leading the way in research of advanced cancer treatments such as Proton Beam Therapy for head and neck cancers. Proton Beam Therapy is a specialized type of radiation therapy that successfully reduces damage to surrounding tissue which in turn lowers the risk of side effects and improves outcomes. A study recently published in the Journal of American Network Open revealed that patients treated with Proton Beam Therapy had a lower risk of overall progression-free and locoregional recurrence than those treated with Intensity-Modulated Radiation Therapy. This significant development in the fight against cancer is a result of the pioneering efforts of Wing-Keen Yap and the other researchers at Chang Gung Memorial Hospital..

[Audio] Wing-Keen Yap a Clinical Lecturer and Consultant Radiation Oncologist at Linkou Chang Gung Memorial Hospital has conducted research into the application of Proton Beam Therapy for Head and Neck Cancers. His research has illustrated that when comparing Intensity Modulated Radiation Therapy (I-M-R-T-) with Proton Beam Therapy (I-M-P-T-) significantly fewer patients who underwent proton beam therapy required a long-term P-E-G tube with only two percent of I-M-R-T patients requiring the tube compared to none of the I-M-P-T patients. These results indicate the potential of proton beam therapy as a highly efficient form of cancer treatment..

MDACC Experience.

MDACC Experience.

[Audio] Wing-Keen Yap MD is a Clinical Lecturer and Consultant Radiation Oncologist at Linkou Chang Gung Memorial Hospital. His research has advanced the use of Proton Beam Therapy for those suffering from head and neck cancers. A summary of recent studies shows that Proton Beam Therapy leads to reduced mucositis reduced analgesic requirements reduced changes in taste and appetite fewer gastrostomy tubes fewer hospitalizations within 60 days of treatment reduced moderate and severe xerostomia and reduced mandibular osteoradionecrosis. Among the authors of these studies were William M Mendenhall MD Jonathan J Beitler MD MBA Nabil F Saba MD FAC Ashok R Shaha MD facs Sandra Nuyts MD PhD Primoz Strojan MD Heleen Boilen MD Oded Cohen MD Robert Smee MD Sweet Ping Ng MD Avraham Eisbruch MD and Wai Tong Ng MD Jessica M Kirwan MA Alfio Ferlito MD. Together they have shown us that Proton Beam Therapy is a safe and effective alternative to traditional cancer treatments..

[Audio] Today I'm going to talk about Ms Huang a 45-year-old lady diagnosed with nasopharyngeal carcinoma stage 3N2cM0 and her successful treatment with proton beam therapy. She underwent intensity-modulated proton therapy which comprised of 70GyE/33 fractions over a period of 7 weeks from 2023/03/06 to 2023/04/20. During this time she experienced grade 2 dermatitis and mucositis as well as grade 1 dry mouth and taste change. However all acute side effects recovered within one month of treatment and there was no need to use a feeding tube either during or after the treatment. Ms Huang has been in complete remission since..

[Audio] Wing-Keen Yap MD is leading the way to advance cancer treatment with Proton Beam Therapy for Head and Neck Cancers. Proton beam therapy is proving to reduce the toxicity of radiation treatments potentially shrinking the long-term impact on patient quality of life. The Proton and Radiation Therapy Center at Chang Gung Memorial Hospital is at the cutting edge of advances in radiation delivery technology utilizing pencil-beam scanning IMP T as the most advanced RT delivery system for PBT. With this technology we are seeing improved normal organ sparing offering potential for improved long-term outcomes..

[Audio] I appreciate your attention and involvement in this presentation. I hope you found the information helpful and applicable in the future. I'm open to any questions you may have and you can contact me through email or WhatsApp. Once again thank you for joining in..