Harbal drug technology

Harbal drug technology. Topic - Preparation and Standardization of.

INTRODUCTION. These are medicines in the form of tablets (vati) and pills (ghutika). They contain single or combinations of herbal, mineral or animal drugs. Vati/Gutika kalpana is a pharmaceutical procedure in which the powder of raw drugs (Herbal or Herbo-minerals) triturated together with certain Kashayam (decoction) or swarasa (fresh extract or juice of plants) or even honey and the medicines are prepared in the form of pills or tablets. Vataka, gutika, vati, modaka, vatika, pindi, guda and varti are the synonyms of vati. Differences may prevail in the shape or size of the above preparations, but the pharmaceutical procedure remains same..

Method of preparation. The drugs are dried and finely powdered, mineral drugs are converted into calcinated products (bhasmas) or any other form as specified. As per the mentioned formula, the drugs and other ingredients are mixed together and made into a soft paste with specified liquids. It is then properly ground and made into vati (tablets) or ghutikas (Pills), Standardization parameters for Vati & Ghutikas > Vati & Ghutikas should be stable up to 2 years after preparation. If they contain only mineral ingredients, they can be used indefinitely. They should not lose their original colour, odour, taste and form upon storage. If they contain sugar/ salt, they should be protected from moisture..

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STANDARDIZATION. Traditional methods : Quality of Gutika can be checked by various parameters Traditionally colour, odour, taste, size, and shape of Gutika can be checked. Modern methods : Although Gutika is considered as traditional formulation, modern quality control and standardization parameters can be employed for it. Mainly Gutika can be evaluated for weight variation, disintegration test, hardness test, LOD, volatile oil content, total ash or even absorption of wavelength under UV spectrophotometer. Physicochemical evaluation : Extractive value, pH, ash value, loss on drying can be used for standardization of Gutika. Qualitative analysis : Phytochemical tests and alkaloid content, glycoside content or sugar content can be done. Chromatography: TLC or HPTLC for content evaluation can be done. Generally, Gutika have two years of shelf life, when stored in airtight containers. Some bhasma or mineral containing Gutika claims no expiry date. However, it should not loose original colour, smell, taste and form.When sugar, jaggery, salt or Kshara ingredients are used in Gutika, it should be kept away from moisture..

EXAMPLES. Lasunadi vati. Pranda gutika. Shankh vati.

CHURNA. Drugs are deaned properly, dried thoroughly, pulverised and then sieved. The Chuma is free floating and retains potency for one year if preserved in air tight containers. Simple Churna consists of only one ingredient while a compound one consists of more than one ingredient. In Ayurvedic systems of treatment, churnas are as exactly as Asavas and Aristas for the abolition of diseases The principle of using Chuma is due to the fact that therapeutic value of most of the substance is greatly increases when they are reduced to very fine state..

METHOD OF PREPARATION. The drug prescribed in the yoga is cleaned, dried, finely powdered and sieved. In case of many drugs, each drug is separately Powdered, sieved and weighed, followed by mixing together all the resultant powder. For large scale production, all the drugs are cleaned, dried, powdered together in disintegrators and then screened through mechanical sifters. The powder should be made fine enough to pass through 80 mesh sieve. The powder particles should not adhere or become moist. The therapeutic efficacy of fine powder is comparatively better..

STANDARDIZATION. Traditional method : The ideal Churna should be free flowing and without lumps or big particles. It should retain its potency for one year, if preserved in airtight containers. It should not change its colour, odour. Modern method : Particle size, angle of repose, flow properties of Churna can be studied by using different modern analytical instruments. Respective biological activity can be done to evaluate Churna. Apart from that pH, ash value, extractive value, moisture content, heavy metal, microorganisms, fibre content can be studied for standardization of Churna..

Examples. TRIPHALA CHURNA. SITOPALADI CHURNA.

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