HERBAL DRUG TECHNOLOGY

HERBAL DRUG TECHNOLOGY. Topic - Preparation and Standardization of.

INTRODUCTION. These are medicines in the form of tablets ( vati ) and pills ( ghutika ). They contain single or combinations of herbal, mineral or animal drugs. Vati / Gutika kalpana is a pharmaceutical procedure in which the powder of raw drugs (Herbal or Herbo-minerals) triturated together with certain Kashayam (decoction) or swarasa (fresh extract or juice of plants) or even honey and the medicines are prepared in the form of pills or tablets. Vataka , gutika , vati , modaka , vatika , pindi , guda and varti are the synonyms of vati . Differences may prevail in the shape or size of the above preparations, but the pharmaceutical procedure remains same ..

Method of preparation. The drugs are dried and finely powdered, mineral drugs are converted into calcinated products ( bhasmas ) or any other form as specified. As per the mentioned formula, the drugs and other ingredients are mixed together and made into a soft paste with specified liquids. It is then properly ground and made into vati (tablets) or ghutikas (Pills), Standardization parameters for Vati & Ghutikas > Vati & Ghutikas should be stable up to 2 years after preparation. If they contain only mineral ingredients, they can be used indefinitely. They should not lose their original colour , odour , taste and form upon storage. If they contain sugar/ salt, they should be protected from moisture..

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STANDARDIZATION. Traditional methods : Quality of Gutika can be checked by various parameters Traditionally colour , odour , taste, size, and shape of Gutika can be checked. Modern methods : Although Gutika is considered as traditional formulation, modern quality control and standardization parameters can be employed for it. Mainly Gutika can be evaluated for weight variation, disintegration test, hardness test, LOD, volatile oil content, total ash or even absorption of wavelength under UV spectrophotometer. Physicochemical evaluation : Extractive value, pH, ash value, loss on drying can be used for standardization of Gutika ...

Qualitative analysis : Phytochemical tests and alkaloid content, glycoside content or sugar content can be done. Chromatography : TLC or HPTLC for content evaluation can be done. Generally, Gutika have two years of shelf life, when stored in airtight containers. Some bhasma or mineral containing Gutika claims no expiry date. However, it should not loose original colour , smell, taste and form.When sugar, jaggery , salt or Kshara ingredients are used in Gutika , it should be kept away from moisture..

EXAMPLES. Lasunadi vati. Pranda gutika. Shankh vati.

CHURNA. Drugs are deaned properly, dried thoroughly, pulverised and then sieved. The Chuma is free floating and retains potency for one year if preserved in air tight containers. Simple Churna consists of only one ingredient while a compound one consists of more than one ingredient. In Ayurvedic systems of treatment, churnas are as exactly as Asavas and Aristas for the abolition of diseases The principle of using Chuma is due to the fact that therapeutic value of most of the substance is greatly increases when they are reduced to very fine state..

METHOD OF PREPARATION. The drug prescribed in the yoga is cleaned, dried, finely powdered and sieved. In case of many drugs, each drug is separately Powdered, sieved and weighed, followed by mixing together all the resultant powder. For large scale production, all the drugs are cleaned, dried, powdered together in disintegrators and then screened through mechanical sifters. The powder should be made fine enough to pass through 80 mesh sieve. The powder particles should not adhere or become moist. The therapeutic efficacy of fine powder is comparatively better..

STANDARDIZATION. Traditional method : The ideal Churna should be free flowing and without lumps or big particles. It should retain its potency for one year, if preserved in airtight containers. It should not change its colour , odour . Modern method : Particle size, angle of repose, flow properties of Churna can be studied by using different modern analytical instruments. Respective biological activity can be done to evaluate Churna . Apart from that pH, ash value, extractive value, moisture content, heavy metal, microorganisms, fibre content can be studied for standardization of Churna ..

Examples. TRIPHALA CHURNA. SITOPALADI CHURNA.

AMERICAN JOURNAL OF PHARMTECH RESEARCH Pharrnacognostical and Phytochernical Evaluation Of Gutika Anjana — An Ocular Ayurvedic Forrnulation Dr- Shashi Prakash Gupta' Dr- D-B-Vaghe1a2 C RS Shukla V Shalakva Dept. 4- Che•nistry Lab- T-P-G- T- Jan•nagar, Gujarat. India ABSTRACT Gunka is an irnportant Ayurvedic forrnulation containing Gairika Saindhzxvu (Sodii Pippa" (Piper Linn.) and Shunthi (Zingiber e:ÜicinaIe Roxb.) as rnain ingredient- All the constituents are available and prepared according to the reference present in Pratishedha- Till date no has carried out to standardize the forrnulation- Hence the present study svas undertaken to standardize the fortnulation through Pharrnacognostical and phartnaceutical evaluation. The sarnple w•as subjected for various Phytochernical pararneter•s like svater soluble extractive alcohol soluble extractive (32-38•6 ash value loss on drying 14.25% the pH HPTI-C- The HPTLC, solvent Toluene:ethyl acetate (9: 1 showed the Of I I at 13 at Thus the characters achieved rnay provide guidelines for standardization of forrnulation— Gutik.a Keysvord:s: Gutik.a HPTLC- Pharr-nacognostieal— Evaluation.

Published online in http://iiam_co_in // 50-54 Formulation and Standardization of ISSN No: 0976-5921 Trivrutadi Gutika - An Ayurvedic Formulation Research Article Keerthy S Namboodiril*, Prathviraj Puranik2, Nagaratna J3 I .PG Scholar 2.HOD & Professor 3. Assistant Professor Department of PG studies in Kaumarabhritya, Sri Dharmasthala Manjunatheshwara College Of Ayurveda and Hospital, Udupi. Abstract Trivrutadi gutika, is an Ayurvedic formulation described in Chakradatta which is useful in conditions such as Udavarta(reverse movement Of vata), It contains ingredients such as Trivrut, Pippali, Haritaki and Guda. It is prepared according to the standard Gutika Kalpana along with modern techniques of Tableting. In the present era, as the changing trends necessitated the establishment of standards for Ayurvedic drugs & formulations and development Of reliable quality protocols using modern techniques Of analysis is extremely important. Gunka(tablet) is standardised by different physicochemical parameters and chromatographic examination including HPTLC fingerprinting. All the parameters like uniformity Of weight, loss on drying, disintegration time, friability, hardness, total ash, water soluble ash and acid insoluble ash were well within the norms specified by the Indian Ayurvedic Pharmacopeia with respect to a tablet. Key Words: Trivrutadi gutika, Childhood constipation, Physicochemical analysis, HPTLC profile Introduction Ayurveda is one of the oldest healing system of Terminalia chebula Retz. Saccharum officinarum according to the standard gutika/tablet preparation.

Pare' UP-SR. 20' 3; Vol_ 4010—'035_ E-ISSN: 0975-8232; P-ISSN: 2320-5148 L'PSR 2013 Vol.4 Issue 10 06 201 Y. STANDARDIZ„VI'ION OF FORM U ON B-c. patera and N.M. Patel 2 in 30 July. 26 2013; 01 2013 •BHUN'MBAD' CHURNA' - AN AYURVEDIC POLYHERBAL North Gujarat U Gujarat, India M _ College Education 2, Gujarat. India H PTLC Gui Gujmt. ABSTRACT: Standardization Of herbal formulation is essential in to the quality Of drugs for therapeutic Thc present is an attempt to standardize an Ayurvedic used in fever and etc. The various organoleptic Characteristics. physico— - tics of Heavy metal and Microbial analysis and high perfonnanee thin layer chromatography analysis. The results Obtained be considered tools for assistance to the regulatory developing standard Of great INTRODUCTION: The W HO) has appreci ated the Of medicinal plants public health guidelines to the member states in their to formulate national on traditional to their including evaluation, safety and efficacy. India having a rich heritage Of traditional constituting •mith its different comrv»nents like Siddha and The Of these traditicml of i w•ith thc perspectives Of safety. and quality •evill helps not only to preserve the traditional heritage but to rati of in In lndia around medicinal plant species have been recorded recently, but than i about plant diseases. Of is essential factor in order to thc purity. safety and efficacy Of drugs based on the concentration Of their active In the present research work. an atternpt was •nade up of herbs used in the treatnwnt Of is a polyherbal ayurvedic rnedicine used as a fever, j and Antidiabetic.

Indian Journal of Traditional Knowledge Vol 19(3), July 2020, pp 558-562 Standardization of ayurvedic formulation caturjata churna using modern techniques Rupak Kumar & Anima Pandey*'+ Dept. of pharmaceutical Sciences & Tw•hnology, BIT Mesra, Ranchi, Jharkhand 835 2 1 5, India E-mail: Received 27 February 2019; revised 07 July 2020 Indian traditional medicine is based on various systems including Ayurveda, Siddha and Unani. The evaluation of these drugs is mostly based on phytcwhemical, pharmacological and allied approaches including various instrumental techniques like chromatography, microscopy and others. The present paper aims to standardize the ayurvedic formulation of caturajata churna containing four ingredients, Darusita, Cinnamomum :eylanicum, Ela, Elettaria cardamomum, Patra, Cinnamomum tamala, Nagakesara, Mesua ferrea using modern technique such as ash values, extractive values moisture content by carrying out all four ingredients of the formulation. preliminary phytochemical screening of caturjata churna was carried out using methanol as solvent. The study was carried out in marketed formulation against in house formulation of caturjata churna. It was observed that almost all the parameters are comparable With the marketed formulation. Some are not due to the geographical variation of the raw materials. Keywords: Caturjata Churna, Micromeritic properties, Mineral estimation IPC Code: Int. Cl.20: A61K 36/00 Standardization Of crude drugs is not an easy procedure because almost all crude drugs are of natural origin. In the case of natural drugs, the therapeutic efficacy is a total effect Of its chemical constituents, so the quality and purity refer to the rup rather than anv of its characters so materials is based on sensory evaluation parameters like shape, size, color, texture, and taste while microscopy involves comparative microscopic ins1Rction Of powdered herbal drug. Further, advances in microscope technology have enhanced the accuracv and canabilities of microsconv as a mean.

FORMULATION AND EVALUATION OF CHURNA FOR DIGESTIVE PROPERTY D. Chamundeeswari a , P. Kanimozhi a, Vasanthkumar a, C.Umamaheswara Reddy a ABSTRACT Back ground: Ayurvedic medicines play an important role in gastro intestinal problems due to safety and efficacy in it. Hence churna meant for digestive prom•rty has been formulated by standard prcx:edures and evaluated by phys iCal and analytical The formulation consists of fine powder (sieve 60 size) of dried rhizomes Of Zingiber officinale, fruits Of Foeniculum vulgarae, barks of Cinnamomum zey/anicum and fruits of Trachyspermum ammi in appropriate proportions (2: 2: I : T ) and mixed well. Physical parameters viz, total ash, acid insoluble ash, Water extractive values, alcohol soluble extractive values and crude fibre content besides heavy metal INTRODUCTION Churna is defined as a fine powder of drug or drugs in Ayurveclic system of medicine. Drugs mentioned in patha, are cleaned properly, dried thoroughly, pu Iverised and then sieved. The churna is free flowing and retains its potency for one year, if preserved in an airtight containers. Triphala churna, Trikatu churna, Drakeshadi churna and Sudharsana churna are some of examples. Churna formulation are similar to powder formulations in Allopathic System Of medicine. In recent days churna is formulated into tablets in order to fix the dose easily. These forms Of medicament are prescribed generally of their particle size. Smaller the particle analysis were carried out. The microbial of formulation for Escherichia coli was also determined. The efficiency of churna for digestive property is determined by finding the amylolytic activity and lipolytic activity and compared with GAS TRAP a marketed formulation for gastritis. Results: Ash values and extractive values were found to be within prescribed its. The arsenic level Was found to be O. 205ppm. Churna did not show the presence of any Escherichia coli and other microorganisms. The churna showed pronounced amylolytic and moderate lipolytic activity when compa red to GAS TRAP proving its efficiency for digestive problem. Key words: A i c Medici Digest i O n , Complementary Therapies (Trachyspermum ammi), Cinnamon (Cinnamomum zeylanicurn) and Fennel vulgare). The formulated churna derived from above said drugs is reported to have a wide range of biological activity. Ginger contains aromatic principle like Zingiberine and bisaboline while pungent principles are gingerols and shogaols. Other components are nerol, geraniol, d-camphor, ß-Phellandrene, linalool, a-farnesene, [1] Shagoal. [21 and also diarylheptanoids such as gingerone A&B. This is used in the treatment of flatulence, colic, indigestion. vomiting, constipation. It also maintains the tonicity of intestine muscle [3,4]. Ajowan was found to contain essential oil that contains 50% thymol. This is use.d in traditional medicine for the treatment of indieestion.

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