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[Audio] There are 7 classes of OAD's available for the management of diabetes The first class is Sulphonylureas examples are Tolbutamide, Glicalazide, and Glimepiride Next class of drugs are Meglitinides examples are Repaglinide and Nateglinide Next class of drugs are Bigunides examples is Metformin Next class of drugs are Thiazolidinedione's examples is Pioglitazone Next class of drugs are Alpha glucosidase inhibitors examples are Acarbose and Voglibose Next class of drugs are SGLT- 2 inhibitors examples are Canagliflozin and Dapagliflozin Next class of drugs are Increatin mimetics where we have two subclasses First is DPP- 4 Inhibitors examples are Sitagliptin, Linagliptin, Sexagliptin , Vildagliptin, Teneligliptin and Evogliptin And second is GLP – 1 Analogue examples are Exenetide and Liraglutide.

[Audio] Now we will understand the mode of action of each class of OAD's Sulphonylureas class of drugs acts as an insulin secretagogue Sulphonylureas binds on SUR receptor present on Beta cell and lowers blood sugar by stimulating the release of insulin by pancreatic beta cells and by inducing increased activity of intracellular insulin receptors.