Hello!

[Audio] Hello everyone !!!!! Welcome to second module on Gluvilda, I am your Learning Partner.

[Audio] In the first module we have seen about basics of Diabetes..

[Audio] Now Lets get started with the second module on management of Diabetes.

[Audio] Management of Diabetes is a complex process and require Tried approach. Diet Exercise And Medication that is Oral Anti Diabetic Drug ( OAD's) or Insulin are among the tried..

[Audio] There are 7 classes of OAD's available for the management of diabetes The first class is Sulphonylureas examples are Tolbutamide, Glicalazide, and Glimepiride Next class of drugs are Meglitinides examples are Repaglinide and Nateglinide Next class of drugs are Bigunides examples is Metformin Next class of drugs are Thiazolidinedione's examples is Pioglitazone Next class of drugs are Alpha glucosidase inhibitors examples are Acarbose and Voglibose Next class of drugs are SGLT- 2 inhibitors examples are Canagliflozin and Dapagliflozin Next class of drugs are Increatin mimetics where we have two subclasses First is DPP- 4 Inhibitors examples are Sitagliptin, Linagliptin, Sexagliptin , Vildagliptin, Teneligliptin and Evogliptin And second is GLP – 1 Analogue examples are Exenetide and Liraglutide.

[Audio] Now we will understand the mode of action of each class of OAD's Sulphonylureas class of drugs acts as an insulin secretagogue Sulphonylureas binds on SUR receptor present on Beta cell and lowers blood sugar by stimulating the release of insulin by pancreatic beta cells and by inducing increased activity of intracellular insulin receptors.

[Audio] Bigunides class of drugs exerts glucose-lowering effect by inhibiting hepatic gluconeogenesis and opposing the action of glucagon..

[Audio] Thiazolidinedione's class of drug selectively stimulates the nuclear receptor peroxisome proliferator-activated receptor gamma ( PPAR-γ). Thiazolidinedione's modulates the transcription of the genes involved in the control of glucose and lipid metabolism in the muscle, adipose tissue, and the liver...

[Audio] Alpha Glucosidase inhibitor class of drugs acts by reversible inhibition of membrane bound intestines α glycosidase hydrolize enzymes which hydrolize oligosaccharides and disaccharides to glucose and other monosaccharides in the brush border of the small intestine.

[Audio] SGLT-2 inhibitors class of drugs reduces reabsorption of filtered glucose and thereby promotes urinary glucose excretion in proximal convoluted tubule SGLT- 2 inhibitors also reduces sodium reabsorption and increases the delivery of sodium to the distal tubule.

[Audio] DPP-4 inhibitors class of drugs binds covalently to the DPP-4 enzyme, showing prolonged inhibition of DPP- 4 enzyme. This raises intact GLP- 1 levels, both after meal ingestion and in the fasting state DPP-4 inhibitors has been shown to stimulate insulin secretion and inhibit glucagon secretion in a glucose-dependent manner..

[Audio] Thank you and stay tuned for the next part on Dapagliflozin as a drug of choice in the management of diabetes ….. Till than For any questions You can find me at.