Chronic pain and depression
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Abstract image of curvy lines. Chronic pain and depression.
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A person standing on a rock while looking at the ocean wave with outstretched arms.
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What is chronic pain?. Rethinking chronic pain The Lancet.
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The link. Chronic pain can enhance the feelings of depression Depression can enhance the level of pain one feels THE LINK - regression and changes to the nervous system that both depression and chronic pain have been proven to cause.
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Changes within the brain – similar pathways. Study 1 Prefrontal cortex synapse deterioration Neurotransmitters regression (monoamine) Inflammation.
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Level of pain and depressive symptoms. Greater pain levels and more areas affected increased risk of long-term depression How well antidepressants work can depend on the level of pain one feels prior Chronic pain in rodents highlighted onset of depressive symptoms.
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Research question. Is it possible to stop the regression of the brain tissue and function due to chronic pain such that depression can be prevented? Modern day medicines (antidepressants, hormone regulators…) have been affective but also come with there own side effects I need your help to tackle this problem by investing. We will look for new ways like alternative therapies, such as massage, chiropractic and physiotherapy.
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IMG_4164_Sqwn2I.mp4. Stakeholders – here is Raelynne Medernach.
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References. Doan, L., Manders , T., Wang, J., (2015). Neuroplasticity Underlying the Comorbidity of Pain and Depression. Hindawi : Neural Plasticity. Vol. 2015, Article ID 504691. 16 Pages. https://doi.org/10.1155/2015/504691 Sheng, J., Liu, S., Wang, Y., Cui, R., Zhang, X., (2017). The Link between Depression and Chronic Pain: Neural Mechanisms in the Brain. Hindawi : Neural plasticity. Vol. 2017, Article ID 9724371. 10 Pages. https://doi.org/10.1155/2017/9724371 Somelar , K., Jürgenson , M., Jaako , K., Anier , K., Aonurm -Helm, A., Zvejniece , L., Zharkovsky , A., (2021). Development of Depression-like Behavior and Altered Hippocampal Neurogenesis in a Mouse Model of Chronic Neuropathic Pain. ScienceDirect. Vol. 1758. https://doi.org/10.1016/j.brainres.2021.147329.