Implementation Research Example on Trachoma

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Esmael Habtamu Ali, Assistant Professor, LSHTM, UK; Bahirdar University, Ethiopia; Co-founder and Executive Director, Eyu -Ethiopia.

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Trachoma. One of the most common neglected tropical diseases (NTDs).

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By the end of this module, you will be able to:. .

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Chapter 1: Promise and Problem. Chapter 2: Living up to the Promise.

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Chapter 1: Promise and Problem. The application of “Promise and Problem” in IR Within the context of trachoma and its elimination strategies Learning Objectives: Understand the Trachoma magnitude and transmission - both global and Ethiopia context Identify the implementation problem in the SAFE strategy of Trachoma control in the Ethiopia context.

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Normal upper tarsal conjunctiva. Close up of a person s tongue Description automatically generated with medium confidence.

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Tarsal conjunctival scarring: “TS”. Close up of a person s mouth Description automatically generated with medium confidence.

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Hyperendemic in many of the poorest and most remote rural areas in 42 countries.

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Contact. Personal factors:. Poor hygiene. Infected Child.

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Surgery to treat the blinding stage of the disease.

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WHO Trachoma Elimination Targets. P revalence of trachomatous trichiasis (blinding stage of trachoma) “unknown to the health system” of <0.2% in adults aged ≥15 years.

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Frequent facial cleanliness, improved living conditions, presence of latrines reduced transmission.

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Despite the positive progresses, the SAFE strategy implementation is not yielding the anticipated results in some hyperendemic settings.

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F&E component of the SAFE strategy are efficacious interventions for trachoma control.

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Chapter 2: Living up to the Promise. The application of “Living up to the Promise” in implementation research Key components in designing and conducting implementation research explained Examples adapted from of a Phased out, ongoing and future IR studies from the Stronger SAFE Project A five-year Wellcome Trust funded project Multiple intervention and implementation effectiveness studies on A, F & E of the SAFE Project is currently undergoing in Ethiopia West Arsi Zone of Oromia Region.

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Learning Objectives:. Understand the three key phases in implementation research.

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Phase 1: Need assessment. Understanding (defining) the implementation problem.

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Stronger SAFE:. Photo by Stronger SAFE project team.

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Most common method used to understand implementation gaps.

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Need Assessment 1: Hygiene Behavior. Observing human contact and hygiene behaviour and practices.

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In-depth observations of households over 27-hour periods.

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There was fidelity issue on the implementation of the F component of the SAFE strategy.

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“E” Interventions if the SAFE focused around improving latrine access and utilisation.

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Photos by Stronger SAFE team. Need Assessment 2: Fly Control.

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Highly clustered transmission of trachoma at the household level.

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Uninfected Child Uninfected household. Need Assessment 2: Fly Control.

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Face Washing Intensity and Frequency Implementation Strategies.

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Diagram Description automatically generated. Face Washing Implementation Strategies: Process.

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Creating Enabling Environment. Diagram Description automatically generated.

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Community Event with Households. soap, soap dish, WASH container with tap & WASH flier.

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Multiple small-scale pilot studies conducted to test the Pull-Push strategy.

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Based on these small-scale studies the following implementation strategies were developed.

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Une image contenant ext rieur personne homme herbe Description g n r e automatiquement.

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Effectiveness – Implementation Hybrid Trial Designs.

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Effectiveness – Implementation Hybrid Type 3 Cluster Randomised Controlled Trial.

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Trial Outline.

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Acceptability. Interviews with implementers ( ease of delivery).

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ABDOU, A., MUNOZ, B. E., NASSIROU, B., KADRI, B., MOUSSA, F., BAARÈ, I., RIVERSON, J., OPONG, E. & WEST, S. K. 2010. How much is not enough? A community randomized trial of a Water and Health Education programme for Trachoma and Ocular C. trachomatis infection in Niger. Tropical Medicine & International Health, 15 , 98-104. OURTRIGHT, P., SHEPPARD, J., LANE, S., SADEK, A., SCHACHTER, J. & DAWSON, C. R. 1991. Latrine ownership as a protective factor in inflammatory trachoma in Egypt. British journal of ophthalmology, 75 , 322-325. CURRAN, G. M., BAUER, M., MITTMAN, B., PYNE, J. M. & STETLER, C. 2012. Effectiveness-implementation hybrid designs: combining elements of clinical effectiveness and implementation research to enhance public health impact. Medical care, 50 , 217-226. EMERSON, P. M., BAILEY, R. L., WALRAVEN, G. E. L. & LINDSAY, S. W. 2001. Human and other faeces as breeding media of the trachoma vector Musca sorbens . Medical and Veterinary Entomology, 15 , 314-320. EMERSON, P. M., CAIRNCROSS, S., BAILEY, R. L. & MABEY, D. C. W. 2000. Review of the evidence base for the ‘F’ and ‘E’ components of the SAFE strategy for trachoma control. Tropical Medicine & International Health, 5 , 515-527. EMERSON, P. M., LINDSAY, S. W., ALEXANDER, N., BAH, M., DIBBA, S.-M., FAAL, H. B., LOWE, K., MCADAM, K. P. W. J., RATCLIFFE, A. A., WALRAVEN, G. E. L. & BAILEY, R. L. 2004. Role of flies and provision of latrines in trachoma control: cluster- randomised controlled trial. The Lancet, 363 , 1093-1098..

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EMERSON, P. M., LINDSAY, S. W., WALRAVEN, G. E. L., FAAL, H., BØGH, C., LOWE, K. & BAILEY, R. L. 1999. Effect of fly control on trachoma and diar rhoea . The Lancet, 353 , 1401-1403. FORSEY, T. & DAROUGAR, S. 1981. Transmission of chlamydiae by the housefly. Br J Ophthalmol , 65 , 147-50. MARX, R. 1989. Social factors and trachoma: a review of the literature. Soc Sci Med, 29 , 23-34. NASH, S. D., STEWART, A. E., ZERIHUN, M., SATA, E., GESSESE, D., MELAK, B., ENDESHAW, T., CHANYALEW, M., CHERNET, A. & BAYISSASSE, B. 2018. Ocular Chlamydia trachomatis infection under the surgery, antibiotics, facial cleanliness, and environmental improvement strategy in Amhara, Ethiopia, 2011–2015. Clinical Infectious Diseases, 67 , 1840-1846. PETERS, D. H., ADAM, T., ALONGE, O., AGYEPONG, I. A. & TRAN, N. 2013. Implementation research: what it is and how to do it. BMJ : British Medical Journal, 347 , f6753. RESNIKOFF, S., PEYRAMAURE, F., BAGAYOGO, C. O. & HUGUET, P. 1995. Health education and antibiotic therapy in trachoma control. Rev Int Trach Pathol Ocul Trop Subtrop Sante Publique , 72 , 89-98, 101-10. STEWART, A. E., ZERIHUN, M., GESSESE, D., MELAK, B., SATA, E., NUTE, A. W., ASTALE, T., ENDESHAW, T., TEFERI, T. & TADESSE, Z. 2019. Progress to eliminate trachoma as a public health problem in Amhara National Regional State, Ethiopia: results of 152 population-based surveys. The American journal of tropical medicine and hygiene, 101 , 1286-1295..

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STOCKS, M. E., OGDEN, S., HADDAD, D., ADDISS, D. G., MCGUIRE, C. & FREEMAN, M. C. 2014. Effect of Water, Sanitation, and Hygiene on the Prevention of Trachoma: A Systematic Review and Meta-Analysis. PLOS Medicine, 11 , e1001605. TAYLOR, H. R., BURTON, M. J., HADDAD, D., WEST, S. & WRIGHT, H. 2014. Trachoma. The Lancet . TAYLOR, H. R., WEST, S. K., MMBAGA, B. B., KATALA, S. J., TURNER, V., LYNCH, M., MUNOZ, B. & RAPOZA, P. A. 1989. Hygiene factors and increased risk of trachoma in central Tanzania. Arch Ophthalmol , 107 , 1821-5. TIELSCH, J. M., WEST, K. P., KATZ, J., KEYVAN-LARIJANI, E., TIZAZU, T., SCHWAB, L., JOHNSON, G. J., CHIRAMBO, M. C. & TAYLOR, H. R. 1988. The Epidemiology of Trachoma in Southern Malawi. The American Journal of Tropical Medicine and Hygiene, 38 , 393-399. WEST, S., MUÑOZ, B., LYNCH, M., KAYONGOYA, A., CHILANGWA, Z., MMBAGA, B. B. & TAYLOR, H. R. 1995. Impact of face-washing on trachoma in Kongwa , Tanzania. Lancet, 345 , 155-8. WORLD HEALTH, O. 2013. Sustaining the drive to overcome the global impact of neglected tropical diseases: second WHO report on neglected diseases, Geneva, World Health Organization. WORLD HEALTH ORGANIZATION WEEKLY EPIDEMIOLOGICAL RECORD 2022. WHO Alliance for the Global Elimination of Trachoma by 2020: progress report, 2021. Wkly Epidemiol Rec. WRIGHT, H. R., TURNER, A. & TAYLOR, H. R. 2007. Trachoma and poverty: unnecessary blindness further disadvantages the poorest people in the poorest countries. Clin Exp Optom , 90 , 422-8..