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A multimodal AI approach to achieve optimal vitamin D status through personalized lifestyle interventions in healthy adults Ion Rezola Artero Department of Product, Genomcore-Made of Genes, Spain University Ramon Llull, Blanquerna, Barcelona, Spain.

Vitamin D deficiency is the new pandemic!.

How long has this been happening?.

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Vitamin D Deficiency. Serum 25(OH)D is widely regarded as the most effective indicator for evaluating one's vitamin D status. It consistently provides insights into the available portions of vitamin D metabolites, even though, theoretically, the bioavailable portions might offer greater clinical insight. According to the majority of experts, a serum/plasma 25(OH)D concentration below 75 nmol/L (or 30 ng/ml) is classified as vitamin D deficiency. If the concentration falls below <25 or <30 nmol/L (equivalent to 10/12 ng/ml), the risk of experiencing osteomalacia and nutritional rickets substantially escalates, thereby indicating a severe vitamin D deficiency..

o O. DISEASES ASSOCIATED WITH VITAMIN D DEFICIENCY.

FACTORS INVOLVED IN VITAMIN D STATUS. Vitamin D status depends on different factors which relies on the biodisponibility and processes related with its synthetic pathways, for example:.

[image] Are You a One Size Fits All Writer. Ricci L, Villegente J, Loyal D, Ayav C, Kivits J, Rat AC. Tailored patient therapeutic educational interventions: A patient-centred communication model. Health Expect. 2022;25(1):276-289..

DATA DRIVEN TECHNOLOGY AS A TOOL FOR PERSONALIZED HEALTH.

HOW CAN TECHNOLOGY HELP US?. Technology enables a much faster processing of all the data that needs to be integrated to achieve a sound clinical decision, allowing for better treatment choices in less time, thus saving the National Health System (NHS) from unnecessary treatments..

Our tool is capable of storing and processing a large amount of data: genetic variants (Single Nucleotide Polymorphisms, SNPs), biochemical markers, and even environmental data through health questionnaires. This streamlined processing of multimodal data allows us to generate personalized recommendations with tailor-made actions for each individual, taking into account all their unique characteristics..

THE KEY POINT. > Nutrients. 2022 Jan doi: 10.3390/nu14020360. Meta-AnaIysis Vitamin D Receptor ( VDR) Gene Polymorphisms Modify the Response to Vitamin D Supplementation: A Systematic Review and Meta-Analysis 345 6 Ricardo Usategui-Martin Daniel-Antonio De Luis-Romån José Maria Fernåndez-G6mez Marta Ruiz-Mambrilla 7 , José-Luis Pérez-Castrillén 458 Affiliations + expand PMID: 35057541 PMCID: PMC8780067 DOI: 10.3390/nu14020360 Free PMC article.

THE KEY POINT. Men-Analysis > Nutrients 2022 Jan doi: 103390,'nu14020360, Vitamin D Receptor ( VDR) Gene Polymorphisms Modify the Response to Vitamin D Supplementation: A Systematic Review and Meta-Analysis Ricardo LJsategui-Martin 2. Daniel-Antonio De Luis-Roman 4 S. José Maria Femåndez-GOmez Marta Ruiz-Mambrilla 7. Jose-Luis Pérez-Castrillön S 8 Affiliations + expand PMID 35057541 PMCID PMC8780067 DOE 10.3390,'nu14020360 Free PMC article.

How many people are affected by these polymorphisms? Could these be behind the significant numbers of Vitamin D Deficiency?.

Study the prevalence of vitamin D supplementation resistance and the actual genetic risk of vitamin deficiency and vitamin D status..

MATERIALS & METHODS. n = 352 Woman & Man. 1 year follow up.

MATERIALS & METHODS. Following the initial analysis, they received guidance tailored to their specific attributes from our personalized manual. The AI-generated recommendations, employing a decision tree approach, were provided through the guideline..

MATERIALS & METHODS. 25-OH Vitamin D. VDR rs2228570 rs731236 GC rs4588 rs7041 CYP2R1 rs10741657.

MATERIALS & METHODS. abstract. Vitamin D. OQQQ. Survey.

29,54% 70,46% Supplementation resistance. Vitamin D Status.

When we investigated whether vitamin D deficiency was more pronounced in one age group than another, we discovered that it is not the case. Instead, we can find it prevalent from youth to old age..

A significant group of individuals (indicated by the blue bar) exhibit a predisposition (GRS) to a deficiency of vitamin D and below-normal analytical values (vitamin D deficiency)..

Evaluating the efficacy of vitamin D supplementation across diverse populations and employing technology to simplify the comprehension of various data inputs can enhance the management of vitamin D deficiency..

NEXT STEPS. Supplementation resistance Non supplementation resistance.

We enable the integration and processing of multimodal high-dimensionality datasets like genomics, blood tests, wearables, clinical records and medical imaging to implement both professional workflows and customer-oriented applications solving real precision health needs in an easy and compliant manner..

abstract. THANK YOU!. Ion Rezola Artero ion.rezola@madeofgenes.com info@madeofgenes.com.

NEXT STEPS. Discover novel approaches to enhance vitamin D status based on the understanding of new key variables related to its plasma levels..